Symbol
Name
ID

Pkd2
polycystin 2, transient receptor potential cation channel
MGI:1099818

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes	Dextrocardia	Situs inversus totalis	Mitral valve prolapse	Aortic root aneurysm	Abnormal systemic arterial morphology	Dilatation of the cerebral artery	Hypertension
Disease(s) Associated with PKD2	Dextrocardia	Situs inversus totalis	Mitral valve prolapse	Aortic root aneurysm	Abnormal systemic arterial morphology	Dilatation of the cerebral artery	Hypertension
autosomal dominant polycystic kidney disease
polycystic kidney disease 2

Mouse Phenotypes

abnormal placenta vasculature

abnormal placental labyrinth vasculature morphology

abnormal hepatic vein morphology

abnormal heart development

abnormal heart looping

atrial septal defect

dextrocardia

mesocardia

atrioventricular septal defect

ventricular septal defect

pericardial effusion

hemorrhage

Availability

Mouse Genotype

Pkd2^lrm4/Pkd2^lrm4

Pkd2^tm1Dwo/Pkd2^tm1Dwo

Pkd2^tm1Gwu/Pkd2^tm1Gwu

Pkd2^tm2Som/Pkd2^tm2Som

Pkd2^tm1.1Tjwt/Pkd2^tm1.1Tjwt
Tg(Tek-cre)1Ywa/0 (conditional)

Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt
Meox2^tm1(cre)Sor/Meox2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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